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How does Hyaluronidase Work?

Hyaluronidase works as an enzyme to temporarily break down hyaluronic acid which is found naturally in the body. This makes it easier for injection of fluids to be administered, and effective absorption of the fluids into the skin and tissue.

Hyaluronidase additionally aids the body to  reabsorb blood and fluids from the tissues, in the case of a large bruise.

What’s in the box?

  • Hyaluronidase enzyme (active ingredient)

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  • 10 amps (1500iu)

What are the benefits of Hyaluronidase? Buy Dermal Filters Online 

  • Aid in the penetration of fluids during subcutaneous and intramuscular injections
  • Hyaluronidase can be directly added to the fluid or solution that is being injected into the skin
  • Aids absorption of a subcutaneous infusion, where Hyaluronidase is injected beforehand into the site of injection where the injection is to be administered
  • To aid the body to reabsorb fluids or blood in hematomas or extravasation, where Hyaluronidase is mixed with saline or water before being injected at the site of injection
  • Breaks down Hyaluronic acid which is present between cells to help them adhesive together. This is a temporary action and helps the quick absorption of fluid injections.

Role in cancer
The role of hyaluronidases in cancer has been historically controversial due to contradictory observations,[12] namely that levels of hyaluronidase (HYAL1/2) are increased in some cancers (colorectal,[13] bladder, prostate, breast, and brain), whereas low expression of HYAL1 is correlated with a decrease in survival of pancreatic adenocarcinoma patients.[14] The reason for this apparent contradiction is that both the accumulation of HA (due to increased HAS levels and decreased HYAL levels), and the degradation of HA into HA oligosaccharides by high HYAL levels result in increased tumor malignancy.[5]

Elevated tissue expression of hyaluronic acid and hyaluronidase validates the HA-Haase urine test for bladder cancer.[15] Limited data support the role of lysosomal hyaluronidases in metastasis, while other data support a role in tumor suppression. Other studies suggest no contribution or effects independent of enzyme activity. Non-specific inhibitors (apigenin, sulfated glycosaminoglycans) or crude enzyme extracts have been used to test most hypotheses, making data difficult to interpret. It has been hypothesized that, by helping degrade the ECM surrounding the tumor, hyaluronidases help cancer cells escape from primary tumor masses. However, studies show that the removal of hyaluronan from tumors prevents tumor invasion.[citation needed] Hyaluronidases are also thought to play a role in the process of angiogenesis, although most hyaluronidase preparations are contaminated with large amounts of angiogenic growth factors.[16]

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